On May 7, 1915, a German U-boat attacked the ship, causing it to sink off the Old Head of Kinsale, killing around 1,200 passengers and crew.
Several activities were organised in Cobh to mark the 109th anniversary.
The tribute began with prayers at the Lusitania Graves in Cobh's Old Church Cemetery. The Commodore Male Voice Choir then gave a musical performance. At the graves, which consist of 20 private burial sites and three mass graves housing 167 fatalities, there was also a wreath-laying ceremony.
The event was moved to Cobh Town Centre later on Monday, with the Lusitania Peace Memorial in Casement Square serving as a gathering place for members of the Royal Naval Association and other nautical and historical groups. Cobh Tourism was in charge of organising Monday's commemoration ceremonies.
To honour the anniversary of the disaster, activities that were held, included talks about the Lusitania and unique displays on the ocean liner at the Lusitania Museum in Kinsale.
The world's most extensive display on the liner's sinking was kept in the Old Head of Kinsale Museum in Cork, which received the wreck from US billionaire Gregg Bemis, who owned the Lusitania ten years ago.